Recently, Professor Pang Daiwen and his team published a review article titled “Artificially regulated synthesis of nanocrystals in live cells” in the National Science Review (NSR). The article provides a detailed introduction to the “spatiotemporal coupling strategy” and “regulation mechanism” for the artificial regulation of the synthesis of inorganic functional nanocrystals in living cells. It systematically summarizes their applications in biological labeling, bioimaging, pathogenic microorganism detection, and the expansion of cell-free quasi-biological synthesis strategies based on this. The challenges faced by this field are also discussed. In the future, with the continuous intersection and integration of multiple disciplines, the “spatiotemporal coupling live cell synthesis” strategy is expected to naturally integrate more inorganic functional materials into biological systems, endowing biological systems with extraordinary capabilities, and achieving the purpose of learning from nature and using it for human benefit. Details of the research can be found at https://doi.org/10.1093/nsr/nwab162