Due to the high mutation rate of the influenza virus and the development of drug resistance, existing protective measures often have limitations. Therefore, there is an urgent need to develop a broad-spectrum and effective prevention method to stop virus infections, especially before the virus enters target cells. Based on this, Professor Pang Daiwen and his team have developed a nanofilm barrier with triple protection functions to prevent influenza virus infections in the lungs. This nanofilm barrier is formed through the self-assembly of amphiphilic polymer polymers (DSPE-PEG) and the antiviral drug Arbidol, which can increase the viscosity of the respiratory environment, physically prevent the virus from invading cells, and shield the interaction between the virus and cells through the hydration layer, while also inhibiting virus replication. This strategy provides new ideas for the broad-spectrum protection of influenza viruses and other respiratory pathogens and has extensive application potential. The research is titled “An Inhalable Nanoshield for Effective Prevention of Influenza Virus Infections” and is published in the ACS Nano journal.